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KMID : 0360220080490010081
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Journal of the Korean Ophthalmological Society
2008 Volume.49 No. 1 p.81 ~ p.90
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Intravitreal Versus Subtenon Injections of Triamcinolone Acetonide for Diabetic Macular Edema
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Kwon Soon-Jae
Shin Jae-Pil
Kim Si-Yeol
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Abstract
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Purpose : To retrospectively evaluate the clinical effect of intravitreal (IVT) and posterior subtenon (PSTT)
triamcinolone acetonide (TA) injection in diabetic macular edema.
Methods : Fifty eyes of 43 patients with diabetic macular edema (DME) were included. Twenty-two eyes in
the IVT group received 4 mg/0.1 ml intravitreal TA injections and 26 eyes in the PSTT group received 40
mg/1.0 ml subtenon TA injections. LogMAR visual acuity and intraocular pressure (IOP) were measured and,
using OCT, central macular thickness (CMT) and total macular volume (TMV) were also measured before and
1, 3, and 6 months postoperatively.
Results : Both groups showed significant decreases in the mean CMT and TMV. The mean CMT in the IVT
group was significantly thinner than that of the PSTT group 1 month postoperatively. The percentage
reduction in CMT and TMV were also greater in the IVT group than the PSTT group 1 month
postoperatively. Both groups showed significant improvements in mean visual acuity, with no significant
difference between the two groups. However, at 1-month postoperative improvement in visual acuity was
significantly greater in the IVT group than the PSTT group. The mean IOP in the IVT group was also greater
than that in the PSTT 1 month postoperatively.
Conclusion : Both injections caused a significant increase in visual acuity and a decrease in CMT and TMV.
The effect was more pronounced in the IVT group. However, the PSTT injection also appeared to be a safe
and effective technique for the treatment of DME.
J Korean Ophthalmol Soc 49(1):81-90, 2008
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KEYWORD
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Diabetic macular edema, Intravitreal injection, Posterior subtenon injection, Triamcinolone acetonide
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